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Big Pharma pays $760 million yearly to the FDA to support the Prescription Drug Users Fee Act (PDUFA) to expedite the approval process for new drugs. The result is that review times of these new drugs dropped from 3 years to 1 year, and they are on the market sooner. The downside is that blackboxwarnings added to previously approved drugs are up 25%, and approved drugs now lose their approval at a higher rate than before PDUFA. The organization Public Citizen advises their readers for greater safety not to take new prescription drugs until they have been approved by the FDA for 7 years.